( c-Jun), thus activating cell growth and proliferation Osteosarcoma viral oncogene homolog ( c-Fos) and Jun oncogene PtdIns(4,5)P2 into Phosphatidylinositol-3,4,5-trisphosphateĪctivated ERK1/2 phosphorylate V-fos FBJ murine PI3K cat class IA (p110-beta) directly, , or via SHCĪctivated PI3K catalyzes transformation of c-Src can activate PI3K reg class IA (p85-alpha)/ May also be realized via Phosphoinositide-3-kinase ( PI3K) H-Ras-independent manner via phosphorylation ofĪlpha-1 adrenergic receptors-dependent ERK1/2 activation H-Ras-independent manner (e.g., via phosphorylation MEK2(MAP2K2))/ Mitogen-activated protein kinase 1 and 3 Mitogen-activated protein kinase kinases 1 and 2 Oncogene homolog ( H-Ras) / v-raf-1 murine leukemia viral oncogene Sevenless homolog ( SOS)/ v-Ha-ras Harvey rat sarcoma viral Sarcoma viral oncogene homolog ( c-Src)/ SHC transforming Calcium/calmodulin-dependent protein kinase II ( CaMK II)/ PTK2B protein tyrosine kinase 2 All these pathways may lead to activation of cell ,, and mobilization of intracellularĬa('2+). ( PtdIns(4,5)P2) to produce Inositol 1,4,5-trisphosphateĪctivation of Ca('2+)-dependent Protein kinase C alphaĬa('2+)-independent Protein kinases C delta and epsilon Hydrolyze Phosphatidylinositol-4,5-bisphosphate G-protein alpha-15 activate Phospholipase C beta 1 G-protein alpha-15 and G-protein alphaĪctivating activity polypeptide O ( G-protein alpha-o). Receptor interact with Transglutaminase 2Īlpha-1B adrenergic receptor couples with All three receptors interact withĪnd Alpha-1B adrenergic receptor couple withĪdrenergic receptor and Alpha-1D adrenergic Nucleotide binding proteins (G-proteins). The activated receptors interact with different Guanine Noradrenaline, activate alpha-1 adrenergic receptors. One of the best studied alpha-1Īdrenergic receptors-stimulated pathways is a Mitogen-activated protein kinase 1 and 3 Physiological processes via different pathways. Receptor, Alpha-1B adrenergic receptor andĪlpha-1D adrenergic receptor. Subtype alpha-1 adrenergic receptors consists of Alpha-1A adrenergic
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